My first few novels I printed out to work with, because that was the only way I could see them differently enough that I could actually read and evaluate the words on the page, not the book in my head. I also had to wait quite a while after writing them before I could actually read the words.

Later, I did manage to train myself to revise on screen, particularly if I change fonts/programs/etc., but I still usually have to do at least one print version for revision somewhere in the process. (I typically do multiple revisions.)

I can do double-sided pages, but I still need a 12-pt font and 1" margins, or there doesn't feel like there's enough room to take notes on it.